Fig. 4
From: Mutational signatures: experimental design and analytical framework
Principles of extracting mutational signatures from experimental samples. a Mutation burdens and profiles of human iPSCs treated with different environmental mutagens. Treatments that generate a mutational signature typically show increased mutation burdens and/or altered mutational profiles in the subclones compared to control (background). Note that effect sizes vary for different perturbations. b Determining experimentally generated mutational signatures