Table 1 A comparison of scMAGeCK with two available methods, MUSIC and MIMOSCA on different features
From: scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens
| Â | scMAGeCK-RRA | scMAGeCK-LR | MUSIC | MIMOSCA |
|---|---|---|---|---|
Analysis method | Rank based | Linear model | Topic model | Linear model |
Permutation | Y | Y | N | Y |
Test for certain expression-based phenotype | Y | Y | N | Y |
Suitable for high MOI | N | Y | N | Y |
Non-linear regulatory relationships | Y | N | NA | N |
Use sgRNA-target information | Y | Y | Y | N |
Use negative control | Y | Y | Y | N |
R/Seurat support | Y | Y | N | N |