Fig. 4

Comparison between the SPIN states and other nuclear organization units. a Percentage of constitutive LADs (cLADs) and facultative LADs (fLADs) in SPIN states Lamina, Lamina_Like, and Near_Lm1-2. cLADs and fLADs are called from DamID data from 6 different human cell lines. b Distributions of SPIN states for significant interaction pairs (CTCF-mediated chromatin loops) based on CTCF ChIA-PET data. c Size of the TADs within each SPIN states. TADs are called by the directionality index (DI) method. d SPIN states boundaries are close to TADs boundaries and CTCF peaks. e A Genome Browser snapshot of the SPIN states together with TADs and cross cell-type Hi-C subcompartments. K562 Hi-C contact map is shown at the top. TADs are called by the DI method. Hi-C subcompartments in multiple cell lines [15] are shown at the bottom. Two highlighted regions in light blue are constitutive B3 subcompartments that correspond to the Lamina SPIN state. The light gray region has more dynamic subcompartment annotations in different cell types. The light orange region highlights a constitutive A1 subcompartment that corresponds to the Speckle SPIN state