Fig. 1
From: Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
Overview of workflow for mapping complex trait-associated QTLs. Full variant association summary statistics results from 114 GWAS were downloaded, standardized, and imputed to the GTEx v8 WGS variant calls (maf > 0.01) for analyses. A total of 8.87 million imputed and genotyped variants were investigated to identify trait-associated QTLs. A total of 49 tissues, 87 studies (74 distinct traits), and 23,268 protein-coding genes and lncRNAs remained after stringent quality assurance protocols and selection criteria. A wide array of complex trait classes, including cardiometabolic, anthropometric, and psychiatric traits, were included