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Fig. 3 | Genome Biology

Fig. 3

From: Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinoma

Fig. 3

HMs bear basic transcriptomic hallmarks of PDAC. a Principal component analysis based on whole transcriptome showed that HMs have similar transcriptome as PTs. As showed in first two principal components that HMs and PTs are closed clustered together. b Compared to Ns, there are many common DEGs shared by PTs and HMs, including 2500 upregulated and 1983 downregulated genes. c Similar as PTs, HMs showed basic molecular hallmarks including loss of pancreatic phenotype, anti-apoptosis, inflammation, metabolic remodeling, dysregulated signaling pathways, and ECM remodeling. Genes showed in heatmap were those common DEGs identified in b. d PTs and HMs shared similar tumor-infiltrating-lymphocytes profiles

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Genome Biology

ISSN: 1474-760X

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