Fig. 4

Time of divergence between major primary and relapse T-ALL clones. a Relationship between the mutation rate of ALL samples and the age of patients. The red line shows the regression line estimated from the data points which are the number of mutations attributed to signature 5 (red dots are primary sample and red crosses represent the relapse) of the in-house adult T-ALL cohort. In pink, the regression line estimate for the pediatric primary samples (here represented as pink dots). The gray cross and triangle correspond to the signature 5 somatic mutations from healthy tissue (MPP and HSC cells) of Osorio et al. [49]. Pearson correlation coefficient (r) is indicated above each of the previously mentioned regression lines. b Schematic representation of the different mutation rate increment models to estimate the divergence time of the leukemic (primary and relapse) cells. c Divergence time of the primary and relapse clone represented as days before diagnosis. The dots are the estimates computed from the models used and the size of the dots represents their likelihood (see Additional file 2: Fig. S8). The dashed line is the weighted mean of the likely model estimates (see Additional file 1: Table S7)