Fig. 2

Comparison of different age groups in T cell acute lymphoblastic leukemia. a Schematic representation of the clinical course of all patients in the in-house T-ALL cohort. Colored boxes (following the legend) at the bottom depict common stages in this clinical course. The broken lines represent specific trajectories followed by groups of patients, with the numbers in each trajectory. b Summary of driver mutations (single nucleotide variants, indels, copy number variants and translocations) identified in the primary and/or relapse T-ALLs of adult and pediatric patients. The original cohorts and age bins of the patients included in the table are indicated above it. The sample where the mutation is identified (primary, relapse, or both) is indicated by color semicircles and circles at each cell of the table. The total number of patients affected by mutations of each gene is indicated by the bars at the right-side of the graph. The table contains the genes that are altered in at least two patients of the adult cohort (for full table see Additional file 2: Fig. S4 and Additional file 1: Table S5). c Protein affecting mutations identified in NOTCH1 gene within adult (above graph) and pediatric (below graph) T-ALLs. Multiple mutations in different samples of a patient in the in-house are represented as dashed colored lines that connect the mutated positions. (No line connects mutations in patients of pediatric cohorts, even if multiple mutations affecting NOTC1 in a patient were observed.) d Clonality change in multi-mutated NOTCH1 pathway genes. Blue and orange squares depict, respectively, primary and relapse T-ALL samples of each patient. Lines connecting them represent shared (connecting lines) or private (lines ending in a cross) NOTCH1 or FBXW7 mutations. In 5 out of 19 patients, only one mutation in this pathway is identified, while in the other 11, multiple mutations are detected. We did not detect any mutation affecting this pathway in only 3 of the 19 patients