Fig. 1From: Multiplex enCas12a screens detect functional buffering among paralogs otherwise masked in monogenic Cas9 knockout screensParalogs are under-represented in CRISPR-Cas9 screens. a Scatter plot of mean vs. standard deviation of log (TPM) gene expression in CCLE. Color coding by component of a 3-element Gaussian mixture model. b Fraction of context and common essentials as a function of gene expression. c Paralog pairwise sequence identity among constitutively expressed paralogs. d Fraction of common essentials with a paralog vs. fraction of never-essentials with a paralog, by paralog similarityBack to article page