Fig. 1
![Fig. 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs13059-020-02173-2/MediaObjects/13059_2020_2173_Fig1_HTML.png)
Paralogs are under-represented in CRISPR-Cas9 screens. a Scatter plot of mean vs. standard deviation of log (TPM) gene expression in CCLE. Color coding by component of a 3-element Gaussian mixture model. b Fraction of context and common essentials as a function of gene expression. c Paralog pairwise sequence identity among constitutively expressed paralogs. d Fraction of common essentials with a paralog vs. fraction of never-essentials with a paralog, by paralog similarity