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Fig. 1 | Genome Biology

Fig. 1

From: Multiplex enCas12a screens detect functional buffering among paralogs otherwise masked in monogenic Cas9 knockout screens

Fig. 1

Paralogs are under-represented in CRISPR-Cas9 screens. a Scatter plot of mean vs. standard deviation of log (TPM) gene expression in CCLE. Color coding by component of a 3-element Gaussian mixture model. b Fraction of context and common essentials as a function of gene expression. c Paralog pairwise sequence identity among constitutively expressed paralogs. d Fraction of common essentials with a paralog vs. fraction of never-essentials with a paralog, by paralog similarity

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