Fig. 2

Bex/Tceal genes show a tissue-enriched expression pattern, particularly in neural organs. a Heatmaps showing relative gene expression levels of Bex and Tceal genes in eight adult tissues/organs using RNA-seq data from five eutherian species: human (Homo sapiens), mouse (Mus musculus), dog (Canis familiaris), cow (Bos taurus), and nine-banded armadillo (Dasypus novemcinctus). In the analyzed organisms, most genes are highly expressed in the brain, particularly Bex genes. Highest and lowest expression levels are represented in red and blue, respectively. b In situ hybridization of Bex and Tceal genes, which show high expression levels (Bex1, Bex2, Bex3, Bex4, Tceal7, and Tceal9) in E13.5 mouse embryos. Sagittal sections of the whole embryo are shown. drg, dorsal root ganglion; ge, gut epithelium; gg gasserian ganglion; he, heart; ki, kidney; li, liver; lu, lung; oe, olfactory epithelium; pe, pancreatic epithelium; Rp, Rathke’s pouch; se, stomach epithelium; sm, skeletal muscle; tg, thyroid gland; tr, thymic rudiment. Scale bar: 1 mm