Fig. 7
From: Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation
Schematic model of CTCF facilitated oncogenic transcriptional activation in T-ALL. a Without gained CTCF binding, intracellular NOTCH1 transcriptional complexes recognize RBPJ, the DNA-binding sequence motif, and recruit SWI/SNF / BAF complexes. b With gained CTCF binding, NOTCH1, BAF complexes, and CTCF protein molecules cooperatively alter the chromosome conformation and form a transcriptional condensate (dashed circle) to regulate expression of the target gene