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Fig. 3 | Genome Biology

Fig. 3

From: Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma

Fig. 3

Effects of MARCOhigh TAMs in vivo and ex vivo. a Representative hematoxylin and eosin staining of mouse brains orthotopically co-implanted with GSCs and either control, monocytes, MARCOlow TAMs, or MARCOhigh TAMs. Each group was injected with 5 mice. b Kaplan-Meier survival curve analysis of the mouse models. c Representative immunohistochemical images of mesenchymal markers including CD44, YKL40, TOP2A, SERPINE1, and BCL2A1 in mouse models. d qRT-PCR analysis of stemness and invasive markers from ex vivo tumor specimens isolated from mouse models. e The 1/stem cell frequency of GSCs isolated from model mice and subjected to 2 or 5 Gy ionizing radiation. *P ≤ 0.05, **P ≤ 0.01, ***, P ≤ 0.001. Data shown in c and e are representative of two independent and reproducible experiments. Data shown in d are representative of three independent and reproducible experiments

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