Fig. 5
From: COCOA: coordinate covariation analysis of epigenetic heterogeneity
COCOA identifies region sets related to a patient phenotype of interest, cancer stage. a Region sets for the polycomb proteins EZH2 and SUZ12 were the top region sets related to cancer stage. b Average DNA methylation level in EZH2-binding regions (the top EZH2 region set) increases with cancer stage. p values by t approximation with null hypothesis that correlation is zero. c Kaplan-Meier curves of the validation samples, grouping samples by average DNA methylation in EZH2-binding regions (25% highest samples and the 25% lowest samples). p value from the log-rank test. e Cox proportional hazards model of average DNA methylation in the top EZH2-binding region set, correcting for age, gender, and average genome methylation level