Skip to main content

Table 3 Comparison of results before and after conditional association analysis. PP posterior probability

From: Primo: integration of multiple GWAS and omics QTL summary statistics for elucidation of molecular mechanisms of trait-associated SNPs and detection of pleiotropy in complex traits

Scenario PP ≥0.9       PP ≥0.8      
  Before accounting for LD    After accounting for LD    Before accounting for LD    After accounting for LD   
  True estFDR Power True estFDR Power True estFDR Power True estFDR Power
  FDR (%) (%) (%) FDR (%) (%) (%) FDR (%) (%) (%) FDR (%) (%) (%)
4a 5.1 2.5 71.3 4.1 4.7 70.3 8.7 4.6 82.8 6.4 8.6 80.8
4b 3.8 2.4 67.4 2.9 5.6 65.7 7.0 4.6 79.2 4.7 10.1 75.9
4c 7.6 2.7 76.4 6.9 3.4 76.3 13.6 5.0 88.5 11.8 7.0 88.0