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Table 3 Comparison of results before and after conditional association analysis. PP posterior probability

From: Primo: integration of multiple GWAS and omics QTL summary statistics for elucidation of molecular mechanisms of trait-associated SNPs and detection of pleiotropy in complex traits

Scenario

PP ≥0.9

     

PP ≥0.8

     
 

Before accounting for LD

  

After accounting for LD

  

Before accounting for LD

  

After accounting for LD

  
 

True

estFDR

Power

True

estFDR

Power

True

estFDR

Power

True

estFDR

Power

 

FDR (%)

(%)

(%)

FDR (%)

(%)

(%)

FDR (%)

(%)

(%)

FDR (%)

(%)

(%)

4a

5.1

2.5

71.3

4.1

4.7

70.3

8.7

4.6

82.8

6.4

8.6

80.8

4b

3.8

2.4

67.4

2.9

5.6

65.7

7.0

4.6

79.2

4.7

10.1

75.9

4c

7.6

2.7

76.4

6.9

3.4

76.3

13.6

5.0

88.5

11.8

7.0

88.0