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Fig. 4 | Genome Biology

Fig. 4

From: Primo: integration of multiple GWAS and omics QTL summary statistics for elucidation of molecular mechanisms of trait-associated SNPs and detection of pleiotropy in complex traits

Fig. 4

Enrichment of CpG targets of breast cancer susceptibility loci among genomic features. a Distribution with relation to islands of CpG targets of Primo-identified multi-omics QTLs and meQTL-only susceptibility loci compared with distribution of all CpGs on 450k array. Numbers represent counts of CpGs in each relationship to islands. b Fold enrichment or depletion of genomic features among CpG targets of multi-omics QTL (cyan) and meQTL-only (pink) susceptibility loci. Feature counts out of total CpG targets are displayed within each bar. X-axis displayed on log scale. P values were obtained by bootstrapping samples of CpGs from the full 450k array [* P<0.01, ** P<10−3]

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Genome Biology

ISSN: 1474-760X

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