Skip to main content

Table 3 Genes significantly associated with AD in at least one test on the ADSP

From: PSCAN: Spatial scan tests guided by protein structures improve complex disease gene discovery and signal variant detection

Gene Pval PSCAN-M Pval PSCAN-V Pval SCAN1D-M Pval SCAN1D-V Pval Burden Pval SKAT #SNP Total #Signal SNP in (PSCAN-M,-V), (SCAN1D-M,-V), SV
BCAM 1.2×10−9 8.1×10−10 1.6×10−9 5.3×10−10 1.4×10−7 8.4×10−10 81 (2,2), (5,5), 2
CBLC 7.3×10−7 2.0×10−7 4.1×10−8 1.7×10−7 8.1×10−7 4.3×10−8 36 (8,8), (5,5), 1
CBX3 1.2×10−5 4.1×10−5 9.7×10−5 4.3×10−5 1.9×10−5 4.1×10−5 6 (4,4), (5,2), 1
SORL1 1.2×10−5 5.5×10−4 3.2×10−5 4.8×10−4 2.1×10−5 2.2×10−2 214 (34,1), (60,7), 0
TREM2 2.5×10−11 8.4×10−11 3.0×10−11 3.2×10−8 7.8×10−11 3.6×10−10 44 (2,1), (27,23), 1
  1. The association test p-values and the numbers of identified signal variants at α=0.05/5=0.01 level are presented