Fig. 3
From: Dysregulation of cancer genes by recurrent intergenic fusions
Recurrent geneUIB fusions that massively upregulate target mRNA. a–j Differential gene expression between the target geneUIB fusion-positive and fusion-negative groups. The ratio between the group means is noted. The BRCA genes are ordered by their expression ratio. Those samples in which the over-expression was less than fourfold compared to the median of the control samples are noted by an asterisk and are excluded from k since they are less likely to be functional. Upstream intergenic breakpoint (UIB) distances were described using gradation color in the fusion-positive group. The UIB distance is defined as the base pair distance from the target gene to the upstream intergenic breakpoint. k A distribution of UIB distances in 10 genes. Notably, 28% of breakpoints (21/75) were more than 2 Mb away from the putative target gene. l The landscape of geneUIB fusion in 40 breast cancer samples. Basal type in PAM50 classification (classifier based on differential expression of 50 genes) is known to assimilate to triple-negative (TN) breast cancer type