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Fig. 5 | Genome Biology

Fig. 5

From: CICERO: a versatile method for detecting complex and diverse driver fusions using cancer RNA sequencing data

Fig. 5

Examples of additional fusions identified by CICERO from TCGA-GBM cohort. The protein domain of the cancer gene involved in a fusion is labeled by colored legend. a Comparison of gene fusions leading to truncation of EGFR C terminal autophosphorylation domain discovered only by CICERO with those reported by both CICERO and the TCGA Research Network. Sites marked as “Closs” refer to out-of-frame C-terminal truncation fusions while those marked with a gene symbol refer to in-frame fusions. b Gene fusions that are likely to cause kinase activation. For the KLHL7-BRAF fusion, we selected the protein encoded by the KLHL7 short isoform NM_001172428 because the fusion breakpoint occurred at the last exon unique to this transcript. c CCDC127-TERT fusion in TCGA-06-2564 leading to over-expression of TERT. Right panel shows the FPKM value of CCDC127 and TERT of the entire GBM cohort with the red dot marking the fusion sample TCGA-06-2564

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