Fig. 1

Oncoplot of the SweGBM-1 tumor cohort, and comparison of mutations in SMG/FMGs between SweGBM-1 and TCGA. a Per sample metadata for age, sex, and molecular type are given in the top three tracks. For the frequently mutated genes (FMGs), mutation incidence is shown as a percentage of the total cohort. Each colored brick shows the somatic alterations seen per sample in the gene (see the inset for the mutation type color code). Genes in magenta represent the significantly mutated genes (SMGs) as discerned by MuTSigCV. The right bar graph shows the rate of mutations per gene, split by mutation type. b For the three SMGs, non-silent mutations are observed in the same protein domains as in the TCGA-GBM dataset