Fig. 7

Functional analysis of gene content by pathway and association of ANTS with cytokine levels. a Functional analysis of gene content by pathway for subsistence using KEGG. Each row represents a subsistence group, and each column represents a gene pathway. Columns are grouped according to the KEGG class. The intensity in each cell represents the mean value of relative enrichment, with dark purple representing high pathway enrichment and dark red representing low pathway enrichment. Cells marked with asterisks denote significance, with *p = 0.05, **p = 0.001, and ***p < 0.001. EIP, environmental information processing; GIP, genetic information processing. b Functional analysis of gene content by pathway for Cameroonians positive or negative for ANTS using KEGG. Each row represents a subsistence group, and each column represents a gene pathway. Columns are grouped according to the KEGG class. The intensity in each cell represents the mean value of relative enrichment, with dark purple representing high pathway enrichment and dark red representing low pathway enrichment. Cells marked with asterisks denote significance, with *p = 0.05, **p = 0.001, and ***p < 0.001. EIP, environmental information processing; GIP, genetic information processing. c Boxplots showing the levels of all cytokines determined as positively correlated with ANTS parasites (Tables S10, S11), binned by positive/negative status. d Boxplots showing the same cytokines indicated as significantly correlated from c but compared across counts of unique ANTS (e.g., a dot in the “4” boxplot is an individual who was positive for all four ANTS). Individuals are counted only once