Fig. 4
From: Lamina-associated domains: peripheral matters and internal affairs
Associations of lamins with chromatin in the nuclear interior. a Lamin associations with chromatin in various intranuclear contexts. A-type lamins interact with euchromatic LADs (via LAP2α) [31, 32] and with promoters and enhancers bound by Polycomb (PRC2) [110,111,112]. Phosphorylated lamin A (lamin A S22ph) also interacts with H3K27ac-rich and active enhancers [113]. Lamins have been shown at the periphery of nucleoli [114, 115], but it remains unclear whether they are implicated in tethering NADs. Lamin B has also been reported to interact with acetylated enhancers and expressed genes during EMT [116] (boxed area). bm6A tracer visualization of lamin B LADs at the nuclear envelope and in the vicinity of nucleoli. Taken from [15] with permission. c Genome browser view of NADs and LADs in a segment of human chromosome 12. Note the overlap between NADs (from [117]) and LADs (from [14])