Fig. 6

The use of the association p value from a related study as a covariate. The p values from an EWAS of systemic lupus erythematosus (SLE) using CD19+ B cells (EWAS28) were used as the covariate to adjust the p values for another EWAS of SLE using CD4+ T cells (EWAS29). a Percent changes in detected DMPs from the ST method for different method and covariate combinations. Changes with more than 1% are displayed in corresponding cells. b Intersections in detected DMPs for the IHW method using different covariates. The connected dots indicate the intersected covariates. Left sidebar indicates the number of DMPs detected by the IHW method using different covariates. As a comparison, the ST method is also included. The intersection size as well as the number of DMPs detected on EWAS28 is indicated on the top. c Top 10 GO terms from enrichment analysis based on the IHW method using the p value from a related study as the covariate. The x-axis indicates the percentage of DMPs in the enriched biological process (out of the total DMPs). And GO terms from top to bottom are arranged in descending order (top 1 to top 10)