Fig. 8
From: Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery
Left: visualization of the parameter space Θ of the VAFs. Orange: somatic variants agree with (θh,θc)∈{0}×(0,1], which means that no healthy cells have the variant (θh=0), while some cancer clones do have the variant (θc>0). Germline variants (blue) are described by \(\theta _{h}\in \{\frac 12,1\}\) and absent variants (red dot) by θh=0,θc=0. Subclonal somatic variants in the healthy (normal) tissue are described by θh∈(0,0.5). Right: diagram of the model presented in the “The model” section (white circles, latent variables; gray circles, observable variables). Each column corresponds to one alignment (\(Z_{i}^{h}\) or \(Z_{j}^{t}\)) with its hyperparameters \(\xi _{i}^{h},\omega _{i}^{h}\) or \(\xi _{j}^{t},\omega _{j}^{t}\). Due to (potential) sample impurity (denoted by α in the text), θh has an influence on the alignments \(Z_{j}^{t}\) from the tumor sample