Fig. 6

IZs form strong compartmental interactions. a Boxplot showing the distribution of PC1 values associated with IZs of early (red), early-mid (blue), late-mid (green) and late (black) timing in H9, H1, HCT116, mESC and mNPC. Black lines indicate medians of distribution. b Average PC1 eigenvector values (top) and pile-up heatmap of PC1 eigenvector values (bottom) centred on H1 IZs ± 1 MB. c Intra-IZ (left) and intra-control (bins in direct proximity to IZs occupying the same genomic space) (right) log10 (obs/exp) interactions binned according to the Hi-C PC1 values associated with the IZ from most the negative to the most positive. d Mean line plots of insulation scores centred at for IZs of early (red), early-mid (blue), late-mid (green) and late (black) timing ± 500 kb in H9, H1, HCT116, mESC and mNPC