Fig. 6
From: Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins
Meta-exon plots reveal intronic regulatory roles. a Each line indicates the presence (in blue) of a reproducible U2AF2 K562 eCLIP peak for 2699 introns that contain at least one peak within the displayed region (500 nt of proximal intron and 50 nt of exon flanking the 5′ and 3′ splice sites). See Additional file 3: Fig. S6a for all 89,265 introns. b Meta-exon plot for data shown in a, with line indicating average and shaded region indicating 5th to 95th percent confidence interval (derived by 100 bootstrap samplings). c (left) Heatmap indicates average peak coverage across all introns for 130 RBPs with at least 100 peaks and 5th percentile confidence interval at least 0.0005 (for heatmap visualization, the maximum value for each dataset was set to one to calculate normalized coverage). (right) Lines show individual RBP examples for five clusters identified based on similar meta-exon profiles. Y-axis indicates fraction of introns with peak