Fig. 2
From: A benchmark of algorithms for the analysis of pooled CRISPR screens
a An overview of the underlying screen parameters that we investigate. b Smoothed density plot of the baseline gene effect size. The vast majority of genes have no effect, while the essential genes with some effect have a long tail. c Example of a smoothed density plot of guide-level log2 fold changes, separated by unknown label. d Smoothed density plot of all guides with the labels hidden, as this is the distribution that must be deconvolved the analyst