Fig. 5
From: Comprehensive assessment of computational algorithms in predicting cancer driver mutations
Assessment using a benchmark dataset based on in vivo tumor formation. a Overview of the assessment process. Cell lines stabling expressing mutant alleles were injected into mice. Mutations that could form any tumors greater than 500 mm3 by 130 days were considered as functional mutations and used as positives, and other mutations were used as negatives. b ROC plot and AUC scores for the top 10 algorithms. c Sensitivity and specificity of 33 algorithms. Error bars, mean ± 2SD