Fig. 4
From: Comprehensive assessment of computational algorithms in predicting cancer driver mutations
Assessment using a benchmark dataset based on the transactivation effects of TP53 mutations. a Overview of the assessment process. Promoter-specific transcriptional activity was measured for 8 targets of p53 protein. Mutations with the median transcription activity ≤ 50% were used as positive cases, and others were used as negative cases. b ROC plot and AUC scores for the top 10 algorithms. c Sensitivity and specificity of 33 algorithms. Error bars, mean ± 2SD