Skip to main content
Fig. 5 | Genome Biology

Fig. 5

From: CTCF modulates allele-specific sub-TAD organization and imprinted gene activity at the mouse Dlk1-Dio3 and Igf2-H19 domains

Fig. 5

Paternal Dlk1 activation during neural differentiation occurs without major intra-TAD reorganization. a Differential non-allelic Hi-C signal upon differentiation of ESCs (orange) to NPCs (green). Hi-C data from reference [11]. b 4C-seq signal for the IG-DMR viewpoint in in vitro differentiated hybrid NPCs and ESCs on the paternal (top) and maternal (bottom) chromosome in the Dlk1-Dio3 TAD. The positions of fosmid probes, the viewpoint, and the sub-TADs (red box: Dlk1-Meg3 sub-TAD) are indicated above. c Distribution of 4C-seq signal for indicated viewpoints in the Dlk1-Meg3 sub-TAD (left) and the combined Dlk1-Meg3 and Mirg-Dio3 sub-TADs (right)

Back to article page

Genome Biology

ISSN: 1474-760X

Contact us