Fig. 1
From: Chromatin interactome mapping at 139 independent breast cancer risk signals
VCHi-C and PCHi-C in human breast cell lines. a Schematic of a hypothetical breast cancer risk signal and plausible chromatin interactions. Chromatin interactions are shown as blue arcs. Genes are depicted as black arrows. CHi-C baits are depicted as gray boxes. CCVs are shown as red vertical lines. The colored boxes illustrate variant-interacting regions (VIRs) or promoter-interacting regions (PIRs). b Principle component analysis of the CHiCAGO-scored interactions in VCHi-C or PCHi-C biological replicates. c Distribution of the CHiCAGO-scored interaction number per bait per cell line (combined biological replicates). d Agglomerative hierarchical clustering for the VCHi-C and PCHi-C in six breast cell lines