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Fig. 6 | Genome Biology

Fig. 6

From: tmap: an integrative framework based on topological data analysis for population-scale microbiome stratification and association studies

Fig. 6

In-depth analysis of enterotype-like stratification of the AGP microbiomes and association with lifestyles. a Stratification of the AGP microbiomes based on enriched taxa. For each node in the TDA network, the most enriched taxon among all taxa is identified according to SAFE enriched score. Each node is colored according to its most enriched taxon. Only taxa enriched in more than 100 nodes are highlighted. Remaining unstratified nodes (with no enriched taxa) are colored in gray. b Stratification based on traditional enterotype analysis. Nodes are colored according to enterotype driver taxa. c Stratification based on countries (USA or UK). Not enriched (or unstratified) nodes are colored in gray. The number in the color legend indicates the number of nodes in the corresponding stratification. d–f Co-enrichment networks of lifestyle factors and taxa. Co-enrichments with countries (USA or UK) are highlighted and extracted. The extracted co-enrichment subnetworks reveal that different lifestyle factors are interrelated to the two countries when accounting for the AGP microbiomes. Node colors are based on metadata category. Node size and edge width are the same as that of Fig. 5

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