Fig. 4From: Genetic regulation of gene expression and splicing during a 10-year period of human agingPopulation- and individual-level allele-specific expression across the genome. a Reference allele proportions (π) at the two ages of each individual are largely consistent (Spearman’s ρ=0.73, across individuals and sites). Blue line shows linear regression fit. b Global allelic imbalance increases with age by 2.69% (median across individuals and sites; Wilcoxon signed rank test; P=1.6×10−2). Distribution of median allelic imbalance ϕ=|π−0.50|) ratio of the two samples of each individual across all heterozygous sites. c Sites with significant local population-level differential ASE with age effects. Six sites show significant differential ASE with age effects. d Six individuals on three genes, i.e., CD52, GNAS, and SH3BGRL3, and four sites show individual-level differential ASE with age (FDR ≤ 5%). Points indicate reference allele proportion for each individual and site; color indicates age. Numbers on top of points show the total number of reads supporting the site at each ageBack to article page