Fig. 1

Regional cell type-specific developmental mCpG trajectories. a Euclidean distances between the samples within cdDMRs show that older neuronal samples cluster separately from infant neuronal samples, glia regardless of age, and bulk prenatal cortex. b Decomposing cdDMR patterns into six clusters using k-means based on glia and neuron mean mCpG changes per year of life. c The top five most enriched Gene Ontology terms for each of the six groups in b highlight diverse biological processes among the groups. No terms were enriched for group 5. d Example of group 3 cdDMR within SNAP25. e Example of group 6 cdDMR within MBP. Gray shading indicates the boundaries of the cdDMR, and black tick marks on the x-axis indicate the position of CpGs. Key: neuron (NeuN+), glia (NeuN−), infant (0–1 year), child (1–10 years), teen (11–17 years), and adult (18+ years)