Fig. 3

MITRE supports exploratory analyses through an interactive visualization interface. The interface allows the user to explore the distribution of learned rules. MITRE was applied to predict diet type from data from David et al. [3] (a–c) or Bokulich et al. [2] (d, e). In a and d, cell colors indicate the strength of evidence that the dynamics of an OTU, or one of its ancestors, during a time window is associated with diet. b, c, e High-probability detectors and phylogenetic subtrees to which they apply. b, c Analyses reveals dynamic behaviors of two different clades, one with butyrate producers and the other without, which distinguish subjects on plant- or animal-based diets. The animal-based diet thus promotes two groups of phylogenetically distinct microbes which are also likely functionally distinct. e Analyses reveal dynamic behavior of a clade of bacteria, associated with a more mature microbiome, which is increased in the predominantly formula-fed infants, suggesting the formula diet may shift infants toward more adult-like gut microbiota. Red lines, threshold slopes/abundances; black lines, median slopes/abundances. Median effect = median over all rules containing the detector