Fig. 6

Timing of chromothripsis and kataegis. a Chromothripsis in crc4015. In the Circos plot on the left, the chromosomes with bold texts are predicted to have chromothripsis and the rearrangements belonging to different chromothripsis events are shown in distinct colors. Rearrangements not part of any chromothripsis are shown in black. The genetic alteration profiles on the right show chromosomes involved in chromothripsis. b Tumor progression map of crc4015. c Chromothripsis in crcA01S. In genetic alteration profiles on the upper right and at the bottom, regions involved in distinct chromothripsis events are marked by colored lines above the chromosome names. Two different regions of chromosome 13 are involved in two separate chromothripsis events. d Tumor progression map of crcA01S. e Rainfall plot for tumor crcA56B. The chromosomes with bold texts are predicted to carry kataegis. f Kataegis associated with chromothripsis, simple SV and complex SV. g Tumor progression map of crcA56B