Fig. 3

Timing of subclonal CNVs, driver SNVs, and driver gene fusions. a Tumor progression map of crc3896. Subclonal copy changes occur before the major clonal expansion. b–d Tumor progression maps of crc3685, crc3807, and crcA01T. Driver SNVs often occur early and before aneuploidy. e Timing of driver fusions. Three out of four driver fusions occur quite early