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Fig. 3 | Genome Biology

Fig. 3

From: CONFINED: distinguishing biological from technical sources of variation by leveraging multiple methylation datasets

Fig. 3

Biological drivers of variability captured by CONFINED across a range of sparsity. We paired a whole-blood dataset [39] with another whole-blood dataset [38] and with a brain dataset [43] to capture sources of variability in each dataset. We fit a linear model for each source of variability using 10 CONFINED components to obtain an R2 value. We varied the percentage of CpG sites used from 1% (nearly entirely sparse) to 100% (no sparsity)

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Genome Biology

ISSN: 1474-760X

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