Fig. 1

3D human genome. Data aggregation and comparison. a Cumulative density plot showing the genomic span distribution of genomic structural elements identified in ChIA-PET and HI-C. b Comparison of Hi-C (lower left) and ChIA-PET (upper right) heatmaps of a 8.5-Mb genomic region in 10 kb resolution. Annotation for chromatin loops (cyan) and domains (purple) from ChIA-PET is presented on the heatmaps. The same ChIA-PET data is shown in a browser view together with ChIP-seq tracks for CTCF and cohesin subunits. The height of an arc indicates the strength of an interaction, which is measured by the number of clustered individual inter-ligation paired-end-tag products. Annotations of genes (GENCODE v12) and enhancers (ChromHMM) are presented. Arrows at genes mark the direction of their transcription. c Similar to b, but a 0.8-Mb genomic region is presented in a heatmap in 1 kb resolution and in a browser view