Fig. 3
From: Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells
Induction of C>U RNA editing and gene expression in NK cells upon cellular crowding and hypoxia/normoxia. a C>U RNA editing in NK cells resulting in non-synonymous changes (n = 62) based in the order of highest to lowest editing level in hypoxia (40 h). Black symbols indicate genes that acquire nonsense RNA editing (n = 10). b Sanger sequence chromatogram traces of amplified cDNA fragments comparing site-specific C>U editing in mRNAs of ten genes under normoxia and hypoxia. c Graph representing the C>U RNA editing levels of based on the location and predicted mutational impact on protein. d Heat map representing the most upregulated genes (n = 50) in NK cells subjected to cellular crowding and hypoxia (cell stress)