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Fig. 4 | Genome Biology

Fig. 4

From: Evolutionarily significant A-to-I RNA editing events originated through G-to-A mutations in primates

Fig. 4

The newly originated RNA editing events are selectively constrained in general. a For the newly originated polyAG editing sites with ancestral state of G, a site frequency spectrum for the derived A allele is shown (Editing Gain). As a background, a list of non-editing, homozygous A sites with ancestral state of G (Control) was used to generate a site frequency spectrum for derived A allele (“Methods”). b For the newly originated polyAG editing sites with ancestral state of A, a site frequency spectrum for the derived G allele is shown (Editing Loss). As a background, a list of non-editing, homozygous G sites with ancestral state of A (Control) was used to generate a site frequency spectrum for derived A allele (“Methods”)

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