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Fig. 3 | Genome Biology

Fig. 3

From: Evolutionarily significant A-to-I RNA editing events originated through G-to-A mutations in primates

Fig. 3

G-to-A mutation as a favorable location for the origination of robust A-to-I editing events. a, b For species-specific (hgG) and A/G polymorphic (polyAG) editing sites, the proportions of sites with ancestral states of G are shown, respectively. The proportions of the adjacent non-edited A sites fixed in the human population as G alleles (hgG Control), or non-edited, polymorphic A/G sites in macaque population (polyAG Control) are also shown as the background. c The distributions of the editing frequency in six macaque tissue types (prefrontal cortex, cerebellum, heart, kidney, muscle, and testis) are shown in boxplots. Sites with different opposite, base-pairing nucleotide in the mRNA secondary structure are shown separately in different bins. d For hgG and polyAG editing sites with ancestral states of G allele or A allele, as well as hgA editing sites as a control, the compositions of the opposite nucleotides (A, T, C, or G) are shown in heatmaps, with the levels of percentage proportional to the color scale

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