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Fig. 2 | Genome Biology

Fig. 2

From: Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects

Fig. 2

Structural variation impacts CRISPR-Cas9 response. ac Representative examples of the strongest associations between SVs and CRISPR-Cas9 LOF. Structural rearrangements are mapped in the upper panel, in the middle panel copy-number levels are represented, and in the lower panel, CRISPR-Cas9 gene level fold changes are shown. SVs are colored with tandem duplications defined with blue lines, deletions with red lines, inversions in green, and chromosome translocations in purple. Average mean values for copy-number (middle panel) and CRISPR-Cas9 fold changes (lower panel) for each copy-number segment are represented as gray lines

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