Fig. 1
From: Illuminating the genome-wide activity of genome editors for safe and effective therapeutics
Charting a course towards safe genome editing. a Like an incomplete nautical map, current methods for defining the genome-wide activities of genome editors identify the locations of potential hazards without offering additional insight into the level of functional risk. b Methods that look below the surface will allow us to understand the level of risk associated with particular hazards and will help to increase confidence in genome-editing strategies