Fig. 9

The comparison of the performance of Fisher’s exact test with GRIPT. The AR and AD models were tested with 0.5%, 1%, 2%, and 3% of patients carrying the pathogenic mutations of RPE65 or TINF2, respectively. The patient cohort size was 600. The control cohort size was 5000. The performance of GRIPT and Fisher’s exact test are shown in red and blue, respectively. a The ranking of RPE65 under the AR model. b The power of the two tests for RPE65. c The number of significant autosomal candidate genes under the AR model. d The ranking of TINF2 under the AD model. e The power of the two tests for TINF2. f The number of significant autosomal candidates under the AD model. The rankings of RPE65/TINF2 generated by GRIPT were compared to those generated by Fisher’s exact test with one-tailed WRST. The methods that generated significantly worse ranking than GRIPT were marked with “*” if p value < 0.05, “**” if p value < 0.01, and “***” if p value < 0.001