Fig. 4

Molecular dynamics simulations of unmodified and 6mA modified DNA. The change after 6mA modification in the mean value of roll (a) and standard deviation (s.d.) (b) as a function of distance from the center of the modification site. The values are averaged over upstream and downstream directions. c, d The same as in a and b but for twist. The average changes after 6mA modification in the s.d. of the inter-base pair (e) and intra-base pair (f) structural parameters. The values are averaged over 3 bp centered at the modification site. The error bars in all panels are ± 1 standard error of the mean