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Fig. 3 | Genome Biology

Fig. 3

From: Phytophthora methylomes are modulated by 6mA methyltransferases and associated with adaptive genome regions

Fig. 3

Bimodal distribution pattern of 6mA around TSS in Phytophthora. The distribution of 6mA peaks around TSS was profiled by MeDIP-seq. The 6mA occupancy along TSS from − 2 to 2 kb is shown. 6mA peaks were enriched around TSS with a bimodal distribution and a local depletion after TSS in P. infestans and P. sojae. a 6mA occupancy in P. infestans methylated genes. All P. infestans genes are divided into 6mA methylated genes (n = 1805) and non-6mA methylated genes (n = 16374). b 6mA occupancy in P. sojae methylated genes. All P. sojae genes are divided into 6mA methylated genes (n = 1343) and non-6mA methylated genes (n = 17853). c Heatmap analyses of 6mA signal from individual genes verified the bimodal distribution pattern in both Phytophthora species. The relative methylation signal is represented using gradient colors. d The 6mA level is negatively correlated with gene expression in P. infestans. All genes are divided into two groups: high expression (FPKM 5, n = 9927) and low expression (FPKM < 5, n = 8252). e The 6mA level is negatively correlated with gene expression in P. sojae. All genes are divided into two groups: high expression (FPKM 5, n = 9450) and low expression (FPKM < 5, n = 9746)

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