From: CRISPR-Cas9 off-targeting assessment with nucleic acid duplex energy parameters
 |  | Off-target scoring method | ||||||
---|---|---|---|---|---|---|---|---|
Area | Â | CRISPRoff | Elevation | CFD | MIT | Cropit | CCTop | VfoldCAS |
ROC | Â | .98 | .96 | .96 | .96 | .91 | .88 | .80 |
PR | Â | .18 | .08 | .08 | .12 | .05 | .06 | .01 |
TPR | Â | Â | Â | Â | Â | Â | Â | Â |
.9 | FPR | .06 | .11 | .11 | .13 | .27 | .34 | .44 |
.95 | Â | .11 | .17 | .17 | .21 | .33 | .44 | .63 |
.99 | Â | .32 | .88 | .88 | .44 | .71 | .74 | .84 |
1 | Â | .73 | .97 | .97 | .96 | .99 | .91 | .96 |
FPR | Â | Â | Â | Â | Â | Â | Â | Â |
.01 | TPR | .67 | .52 | .52 | .59 | .36 | .31 | .18 |
.05 | Â | .89 | .80 | .80 | .79 | .49 | .50 | .39 |
.1 | Â | .94 | .89 | .89 | .87 | .71 | .61 | .48 |