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Table 1 Models on predicting the mutation rate of a potential nonsense site in URA3

From: Reduced intrinsic DNA curvature leads to increased mutation rate

 

Model

AIC

1

Null model

440

2

Mutation rate ~ “0” *

418

3

Mutation rate ~ “0” + “+ 1” + “– 1”

426

4

Mutation rate ~ “0” + “+ 1” + “+ 2” + “+ 3” + “– 1” + “– 2” + “– 3”

432

5

Mutation rate ~ curvature **

433

6

Mutation rate ~ “0” + curvature

414

  1. *“0” represents the nucleotide at the potential nonsense site. “+ 1” and “– 1” represent the downstream and the upstream nucleotide of the potential nonsense site, respectively
  2. **The intrinsic DNA curvature in a 101-bp region from 50 bp upstream to 50 bp downstream of the potential nonsense site