Fig. 3
From: Reduced intrinsic DNA curvature leads to increased mutation rate
Mutations in human tumors are enriched in DNA regions with a smaller intrinsic DNA curvature. a Mutations are enriched in regions with a significantly smaller curvature in all 26 cancer types. Each dot represents a cancer type. P values were calculated based on the permutation test. P values were arbitrarily assigned to 0.001 when P < 0.001. b, c Examples in lung (b) and in kidney (c) showing that the average intrinsic DNA curvature of SNV-containing regions (red arrows) was significantly smaller than the random expectation (histogram showing 1000 permutations)