Fig. 3

Linking distal regulatory elements and SNPs with their target genes with the 3D Genome browser. a Capture Hi-C data in naïve B cells showing potential interactions (green curve lines) with PAX5 promoter region. The Capture Hi-C interactions are consistent with patterns from the 5-kb resolution Hi-C data in GM12878 cells. b Using virtual 4C, DHS-linkage, and ChIA-PET data to hypothesize the target gene for non-coding variant rs12740374. Based on the annotation by chromHMM in HepG2, this SNP is located at a putative enhancer region (orange). According to virtual 4C data, there is a potential interaction between this enhancer and the SORT1 promoter. This linkage is also supported by DHS-linkage, as well as by the H3K4me3 and POL2A ChIA-PET data in K562 cell line