Fig. 2

Examples of using the 3D Genome Browser to explore Hi-C data. a A 10-Mb region of GM12878 Hi-C interaction map on chr12 (~ 15–25 Mb) at 25-kb resolution. The alternating yellow and blue bars are predicted TADs. The dark red bars are DHS in the same cell type. b Hi-C interaction map in K562 cells at 5-kb resolution. The black arrow points to a potential tissue-specific interaction between the SLC25A37 promoter and a candidate enhancer region (marked by H3K4me1). The ChIP-Seq tracks for histone modifications, and chromHMM are visualized using the WashU Epigenome Browser